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Synthesis, characterization and spectral studies of various newer 4‐benzyloxy‐1 H ‐indole‐2‐carboxylic acid (arylidene)‐hydrazides
Author(s) -
Jain Asheesh Kumar,
Gupta Pradeep Kumar,
Ganesan Kumaran,
Pande Ambuja,
Pardasani Deepak,
Malhotra Ramesh Chandra
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420537
Subject(s) - chemistry , hydrazide , carboxylic acid , indole test , organic chemistry , microwave irradiation , fragmentation (computing) , catalysis , computer science , operating system
4‐Benzyloxyindole‐2‐carboxylic acid hydrazide reacts with aromatic and heterocyclic aldehydes in alcoholic medium in refluxing conditions to give 4‐benzyloxy‐1 H ‐indole‐2‐carboxylic acid (arylidene)‐hydrazides, important synthetic intermediates for the synthesis of a newer class of pharmacologically active compounds. We describe here the synthesis of various 4‐benzyloxy‐1 H ‐indole‐2‐carboxylic acid (arylidene)‐hydrazides by conventional as well as microwave irradiation techniques. The structures of these compounds have been confirmed by spectroscopic techniques (FTIR, NMR and MS). Some of the interesting features of the electron impact mass spectral fragmentation pattern of these compounds are also discussed.