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Synthesis and antiviral evaluation of some carbonucleoside analogues
Author(s) -
Alho Miriam A. Martins,
Errea Maria I.,
Sguerra Vanesa L.,
D'Accorso Norma B.,
Talarico Laura B.,
García Cybele C.,
Damonte Elsa B.
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420536
Subject(s) - chemistry , junin virus , furanose , herpes simplex virus , dengue virus , virus , sindbis virus , virology , stereochemistry , biochemistry , organic chemistry , ring (chemistry) , rna , in vitro , lymphocytic choriomeningitis , cytotoxic t cell , gene , biology
1,2‐ O ‐Isopropylidene‐α‐L‐threofuranosyl heterocyclic derivatives were synthesized from 1,2‐ O ‐iso‐propylidene‐α‐D‐xilopentadialdo‐1,4‐furanose and tested for antiviral activity against herpes simplex virus type 1, dengue virus type 2 and Junin virus. For comparative propose, the antiviral activity of some of their pyranosyl analogues were also tested. The furanosyl derivatives showed to be moderate inhibitors of Junin virus and, in general, proved to be more effective than the pyranosyl analogues.