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Synthesis of hantzsch 1,4‐dihydropyridines under solvent‐free condition using zn[(L)proline] 2 as lewis acid catalyst
Author(s) -
Sivamurugan V.,
Kumar R. Suresh,
Palanichamy M.,
Murugesan V.
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420534
Subject(s) - chemistry , catalysis , proline , lewis acids and bases , lewis acid catalysis , yield (engineering) , solvent , microwave irradiation , organic chemistry , amino acid , biochemistry , materials science , metallurgy
The present short communication describes a Lewis acid (Zn[(L)proline] 2 ) catalysed one pot synthesis of Hantzsch 1,4‐dihydropyridine (DHP) derivatives under solvent‐free condition by conventional heating and microwave irradiation. The Lewis acid catalyst Zn[(L)proline] 2 used in this reaction afford moderate to good yield. The catalyst is reusable upto five cycles without appreciable loss of its catalytic activity.