Synthesis of 2‐amino‐4,5‐dihydro‐3‐methanesulfonylfurans (and ‐thiophenes) | Zendy

Yamagata Kenji | Zendy; Okabe Fumi | Zendy; Maruoka Hiroshi | Zendy; Tagawa Yoshinobu | Zendy

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Synthesis of 2‐amino‐4,5‐dihydro‐3‐methanesulfonylfurans (and ‐thiophenes)

Author(s) -

Yamagata Kenji,

Okabe Fumi,

Maruoka Hiroshi,

Tagawa Yoshinobu

Publication year - 2005

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570420531

Subject(s) - chemistry , amino acid , stereochemistry , organic chemistry , combinatorial chemistry , biochemistry

2‐Amino‐4,5‐dihydro‐3‐methanesulfonylfurans 7 and 2‐amino‐4,5‐dihydro‐3‐methanesulfonylthiophenes 8 were prepared by deamidation of tetrahydro‐2‐imino‐3‐methanesulfonyl‐3‐furancarboxamides 3 and of tetrahydro‐2‐imino‐3‐methanesulfonyl‐3‐thiophenecarboxamides 4 with bases. Compounds 3 and 4 were obtained by reaction of 2‐amino‐4,5‐dihydro‐3‐furancarboxamides 1 and 2‐amino‐4,5‐dihydro‐3‐thio‐phenecarboxamides 2 with methanesulfonyl chloride in the presence of triethylamine.

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