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Synthesis and prediction of bioactivity of new nitroimidazole derivatives
Author(s) -
Kowalski Piotr,
Nowak Krystyna,
Szpakiewicz Barbara
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420521
Subject(s) - nitroimidazole , chemistry , antiprotozoal , metronidazole , polar surface area , combinatorial chemistry , stereochemistry , polar , organic chemistry , antibiotics , molecule , biochemistry , in vitro , physics , astronomy
Syntheses of 1‐propyl derivatives of 2‐methyl‐5‐nitroimidazole ( 11‐17 ), containing various azanaphtha‐lene systems attached at 3‐position of the propyl group have been described. Due to structural similarity of the derivatives 11‐17 with metronidazole, an antibacterial and antiprotozoal drug, pharmacological properties of the target compounds were predicted using the PASS program. Polar surface area (PSA) parameter was also applied for estimation of the physical properties of 11‐17 as drug‐like candidates.