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Selective nucleophilic replacement of the benzylsulfanyl group in 2,4‐disulfanyl‐substituted thieno[2,3‐ d ]pyrimidin‐6‐carboxylic acid derivatives by secondary amines
Author(s) -
Briel Detlef,
Drescher Simon,
Dobner Bodo
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420514
Subject(s) - chemistry , nucleophile , residue (chemistry) , carboxylic acid , group (periodic table) , medicinal chemistry , stereochemistry , organic chemistry , catalysis
Thieno[2,3‐ d ]pyrimidines with benzylsulfanyl and allylsulfanyl group in the presence of other alkylsul‐fanyl substituents react selectively under mild conditions with secondary amines under replacement of the benzyl or allyl residue whereas the other substituents remain intact. This enables the synthesis of different basic substituted derivatives with potentially biologically activity.