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A novel route to the 5,6‐dihydro‐4‐H‐thieno[3,2‐b]pyrrol‐5‐one ring system involving an intermediate substituted‐thiophene synthesis
Author(s) -
Hu Shuanghua,
Huang Yazhong,
Poss Michael A.,
Gentles Robert G.
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420427
Subject(s) - chemistry , thiophene , ring (chemistry) , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry
A novel route to electron‐deficient thienopyrrolones is disclosed. The target heterocycles are concisely constructed by condensation of activated α‐ or β‐halo‐substituted acrylonitriles, or ortho ‐substituted halo, cyano heterocycles with mercaptopyruvate, followed by reduction and subsequent lactamization.