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Design and synthesis of novel sulfone‐containing pyrazolo[1,5‐ a ]‐pyrimidines and pyrazolo[5,1‐ d ][1,2,3,5]tetrazine‐4(3 H )‐ones
Author(s) -
Wu YanChao,
Zou XiaoMao,
Hu FangZhong,
Yang HuaZheng
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420421
Subject(s) - chemistry , sulfone , tetrazine , stereochemistry , series (stratigraphy) , combinatorial chemistry , organic chemistry , paleontology , biology
A series of novel sulfone‐containing pyrazolo[1,5‐ a ]pyrimidines ( 2‐3 ) and pyrazolo[5,1‐ d ][1,2,3,5]tetra‐zine‐4(3 H )‐ones ( 5a‐5k ) were designed and efficiently synthesized, some of which have been identified as being potential rape inhibitors. These results widen the structural diversity of rape inhibitors and confirm the perspectives of further investigations in this area. Moreover, a plausible reaction mechanism is outlined.