Pyrimido[4,5‐ c ]pyridazine‐5,7(6 H , 8 H )‐diones: Marvelous substrates for study of nucleophilic substitution of hydrogen | Zendy

Pozharskii Alexander F. | Zendy; Gulevskaya Anna V. | Zendy

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Pyrimido[4,5‐ c ]pyridazine‐5,7(6 H , 8 H )‐diones: Marvelous substrates for study of nucleophilic substitution of hydrogen

Author(s) -

Pozharskii Alexander F.,

Gulevskaya Anna V.

Publication year - 2005

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570420304

Subject(s) - chemistry , pyridazine , nucleophilic substitution , annulation , nucleophile , hydrogen chloride , substitution reaction , medicinal chemistry , hydrogen , substitution (logic) , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , computer science , programming language

The data on nucleophilic substitution reactions of hydrogen in 6,8‐dimethylpyrimido[4,5‐ c ]pyridazine‐5,7(6 H ,8 H )‐dione, its 3‐chloride, N 2 ‐oxide and some other derivatives are reviewed. All these compounds possess a remarkable ability to undergo not only simple functionalizations but also tandem and cascade transformations leading to annelation of various heterocyclic rings.

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