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Pyrimido[4,5‐ c ]pyridazine‐5,7(6 H , 8 H )‐diones: Marvelous substrates for study of nucleophilic substitution of hydrogen
Author(s) -
Pozharskii Alexander F.,
Gulevskaya Anna V.
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420304
Subject(s) - chemistry , pyridazine , nucleophilic substitution , annulation , nucleophile , hydrogen chloride , substitution reaction , medicinal chemistry , hydrogen , substitution (logic) , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , computer science , programming language
The data on nucleophilic substitution reactions of hydrogen in 6,8‐dimethylpyrimido[4,5‐ c ]pyridazine‐5,7(6 H ,8 H )‐dione, its 3‐chloride, N 2 ‐oxide and some other derivatives are reviewed. All these compounds possess a remarkable ability to undergo not only simple functionalizations but also tandem and cascade transformations leading to annelation of various heterocyclic rings.