Premium
Synthesis of some pyrazole‐3‐carboxylic acid‐hydrazide and pyrazolopyridazine compounds
Author(s) -
İlhan İ Özer,
Saripinar Emin,
Akçamur Yunus
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420117
Subject(s) - chemistry , phenylhydrazine , hydrazide , pyrazole , yield (engineering) , furan , carboxylic acid , carbon 13 nmr , elemental analysis , organic chemistry , pyrazolone , medicinal chemistry , metallurgy , materials science
Furan‐2,3‐diones 1a‐c react with various hydrazines 2a‐c under different conditions to yield the pyrazole‐3‐carboxylic acid‐hydrazide 3a‐d . Cyclocondensation reactions of 1a or 7 with phenylhydrazine lead to derivatives of pyrazolo[3,4‐ d ]pyridazinones 6 and 8 , respectively. The structures of all products were confirmed by elemental analysis, IR, 1 H‐ and 13 C‐NMR spectroscopic measurements.