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Synthesis of one‐, two‐ and three‐ring macrocyclic, bifunctional compounds for use in radiolabelling monoclonal antibodies
Author(s) -
Rami Martalena,
Dong Ying,
Lindoy Leonard F.,
Smith Suzanne V.,
Wilson J.Gerald
Publication year - 2005
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570420111
Subject(s) - bifunctional , chemistry , ring (chemistry) , reagent , monoclonal antibody , combinatorial chemistry , stereochemistry , organic chemistry , antibody , catalysis , immunology , biology
The synthesis of new linked bis‐ and tris‐ring tetraazamacrocyclic (bifunctional) reagents for use in an alternative strategy for radiolabelling antibodies is described. For comparison with the above systems, a new single ring bifunctional system incorporating a dioxocyclam ring is also reported.