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The preparation of benzoisothiazolo[1,2‐ b ][1,2]isoquinolin‐11‐one‐1,1‐dioxides from dilithiated ortho ‐toluic acids and lithiated methyl 2‐(aminosulfonyl)benzoate
Author(s) -
Dunn S. Patrick,
Walters Matthew J.,
Metz Clyde R.,
Beam Charles F.,
Pennington William T.,
Krawiec Mariusz
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410626
Subject(s) - lithium diisopropylamide , chemistry , ring (chemistry) , medicinal chemistry , lithium (medication) , organic chemistry , deprotonation , ion , medicine
Select dilithiated ortho ‐toluic acids were prepared in excess lithium diisopropylamide and condensed with methyl 2‐(aminosulfonyl)benzoate followed by a twofold cyclization of intermediates to afford benzoisothiazolo[1,2‐ b ][1,2]isoquinolin‐11‐one‐1,1‐dioxides, a new fused‐ring heterocyclic system.