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Transformation of schiff bases derived from alpha‐naphthaldehyde. Synthesis, spectral data and biological activity of new‐3‐aryl‐2‐(α‐naphtyl)‐4‐thiazolidinones and N ‐aryl‐ N ‐[1‐(α‐naphthyl)but‐3‐enyl]amines
Author(s) -
Kouznetsov Vladimir,
Rodríguez William,
Stashenko Elena,
Ochoa Carmen,
Vega Celeste,
Rolón Miriam,
Pereira David Montero,
Escario José A.,
Barrio Alicia Gémez
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410624
Subject(s) - chemistry , aryl , aldimine , bromide , reagent , antifungal , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , medicine , alkyl , dermatology
New N‐aryl substituted 2‐(α‐naphthyl)‐4‐thiazolidinones were prepared by the cyclocondensation of α‐mercaptoacetic acid and corresponding N ‐(α‐naphthyliden)anilines. The same starting materials were utilized to obtain a new series of N ‐aryl‐ N ‐[1‐(α‐naphthyl)but‐3‐enyl]amines, which was synthesized through an addition of the Grignard reagent (allylmagnesium bromide) to the double bond CN of the aldimines. The antichagasic and trichomonacidal in vitro activity, as well as, the antifungal and cytotoxic properties of some of these compounds were evaluated.