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Improved studies of cross‐coupling reactions of 5‐(tri‐ n ‐butystannyl)‐ and 5,5′‐bis(tri‐ n ‐butylstannyl)‐2,2′‐bithiophene with aryl halides
Author(s) -
Hamad Elgazwy AbdelSattar S.
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410517
Subject(s) - stille reaction , aryl , chemistry , halide , iodide , bromide , yield (engineering) , organic chemistry , coupling reaction , medicinal chemistry , catalysis , alkyl , materials science , metallurgy
Stille coupling under standard conditions proceeds in low yield when using hindered organostannanes (1) or (2) and aryl bromide partners. The inclusion of aryl iodide instead of aryl bromide with the same organostannanes, significantly improves the efficiency of the coupling, providing a variety of desired products in good to excellent yield. The yields of Stille coupling are compared to the different reactivity of aryl halides. This study of Stille coupling with different aryl halides are documented and rationalized.