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Synthesis of highly symmetric mesomeric triazaphenalene betaines
Author(s) -
Kafka Stanislav,
LarisseggerSchnell Barbara,
Kappe Thomas
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410511
Subject(s) - chemistry , guanidine , pyrimidine , salt (chemistry) , benzene , condensation , medicinal chemistry , organic chemistry , stereochemistry , physics , thermodynamics
The synthesis of seven mesomeric triazaphenalene betaines 4a‐g by condensation reaction of hexahydro‐2 H ‐pyrimido[1,2‐ a ]pyrimidine 1 with diethyl malonates 2a‐g or with bis(2,4,6‐trichlorophenyl)malonates 3c,f has been achieved. The guanidine 1 forms in benzene solution a salt with trimethyl methanetricarboxylate 5 which upon heating produces 4a.