Premium
Ring closure reactions of 3‐arylhydrazonoalkyl‐quinolin‐2‐ones to 1‐aryl‐pyrazolo[4,3‐ c ]quinolin‐2‐ones
Author(s) -
Stadlbauers Wolfgang,
Hojas Gerhard
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410505
Subject(s) - chemistry , quinoline , aryl , ring (chemistry) , closure (psychology) , differential scanning calorimetry , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , thermodynamics , alkyl , physics , economics , market economy
4‐Hydroxy‐3‐arylhydrazonoalkyl‐2‐quinolones 6 or reactive derivatives such as 3‐arylhydrazonoalkyl‐4‐tosyloxy‐2‐quinolones 7 or 4‐chloro‐3‐arylhydrazonoalkyl‐2‐quinolones 14 , which are obtained via 3‐acyl‐4‐hydroxyquinolones 4, 10 or 3‐phenylarrmomethylene‐quinoline‐2,4‐diones 12 , cyclize in excellent yields to 1‐aryl‐pyrazolo[4,3‐ c ]quinolin‐4‐ones (11). The cyclization conditions were investigated by differential scanning calorimetry (DSC).