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4‐hydroxy‐6‐methyl‐3‐(5‐phenyl‐2 E ,4 E ‐pentadien‐1‐oyl)‐2 H ‐pyran‐2‐one: Synthesis and reactivity with amines
Author(s) -
AïtBaziz Nabila,
Rachedi Yahia,
Hamdi Maamer,
Silva Artur M. S.,
Balegroune F.,
Thierry Roisnel,
Sellier N.
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410417
Subject(s) - chemistry , pyran , reactivity (psychology) , nucleophile , ethylamine , hydrazine (antidepressant) , conjugated system , medicinal chemistry , stereochemistry , ring (chemistry) , organic chemistry , catalysis , biochemistry , medicine , polymer , alternative medicine , pathology
The synthesis and reactivity studies of 4‐hydroxy‐6‐methyl‐3‐(5‐phenyl‐2 E ,4 E ‐pentadien‐1‐oyl)‐2 H ‐pyran‐2‐one 2 with nucleophiles are reported. Reactions of 2 with hydrazine derivatives gave new pyrazole‐type com pounds while the reaction with ortho ‐phenylenediamines yielded 1,5‐benzodiazepines. The reaction of 2 with ethylamine implies the 2 H ‐pyran‐2‐one ring opening and the formation of a strong conjugated compound 3.