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Synthesis and characterization of new biologically active 2‐(1,3‐disubstituted pyrazolyl)chromones and corresponding pyrimidine, thiopyrimidine, pyrazolyl derivatives
Author(s) -
Joshia N. S.,
Karale B. K.,
Gill C. H.,
Bhirud S. B.
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410410
Subject(s) - chemistry , pyrimidine , phosphodiesterase , combinatorial chemistry , biological activity , organic chemistry , stereochemistry , in vitro , biochemistry , enzyme
A series of 2‐(1‐methyl‐3‐ n ‐propylpyrazol‐5‐yl)‐chromones with interesting Phosphodiesterase IV inhibitition activities were synthesized. Different derivatives of the titled compounds like aminopyrimidine, thiopyrimidine, pyrazolyl were synthesized and their Phosphodiesterase IV inhibitition activities were checked.