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Synthesis of trifluoromethylated pyrido[2,3‐ d ]pyrimidine‐2,4‐diones from 6‐aminouracils and trifluoromethylated pyrazolo[3,4‐ b ]‐pyridines from 5‐aminopyrazoles
Author(s) -
Takahashi Masahiko,
Nagaoka Hironori,
Inoue Kazuhiro
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410408
Subject(s) - chemistry , pyrimidine , trifluoromethyl , medicinal chemistry , bicyclic molecule , stereochemistry , organic chemistry , alkyl
5 or 7‐Trifluoromethyl‐1,2,3,4‐tetrahydropyrido[2,3‐ d ]pyrimidine‐2,4‐diones 3 , 5 , 10 , 13 and 4‐ or 6‐trifluoromethylpyrazolo[3,4‐ b ]pyridines 15 , 16 , 19 , 21 were prepared from 6‐aminouracils and 5‐aminopyrazoles, respectively, in good yields by the use of building blocks such as 4,4,4‐trifluoro‐1‐phenyl‐1,3‐butanedione, 1,1,1‐trifluoro‐4‐phenyl‐3‐buten‐2‐one, 4‐ethoxy‐1,1,1‐trifluoro‐3‐buten‐2‐one, and ethyl trifluoroacetoacetate.