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Synthesis, NMR spectra and X‐ray data of chloro and dichloro derivatives of 3‐hydroxy‐2‐phenylquinolin‐4(1 H )‐ones and their cytostatic activity
Author(s) -
Hradil Pavel,
Krejčí Petr,
Hlaváč Jan,
Wiedermannová Iveta,
Lyčka Antonín,
Bertolasi Valerio
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410311
Subject(s) - chemistry , nmr spectra database , spectral line , characterization (materials science) , combinatorial chemistry , biological activity , stereochemistry , nanotechnology , in vitro , biochemistry , physics , materials science , astronomy
Abstract As known, some derivatives of quinolin‐4(1 H )‐one possess interesting biological properties. The biological and cytostactic activity of 2‐substituted 3‐hydroxyquinolin‐4(1 H )‐ones has not been reported yet. In this paper the synthesis of a series of chloro and dichloro 2‐phenyl‐3‐hydroxyquinolin‐4(1 H )‐ones and their characterization by NMR spectra and X‐ray data is described. Their cytostatic properties have been evaluated and the results are reported.