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Synthesis of polyfunctionally substituted heteroaromatic compounds via benzotriazolyl chalcones with antimicrobial and antifungal activities
Author(s) -
AlOmran Fatima,
ElKhair Adel Abou
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410304
Subject(s) - chemistry , isoxazole , antimicrobial , chalcone , antifungal , pyridine , pyrazole , organic chemistry , medicinal chemistry , combinatorial chemistry , microbiology and biotechnology , biology
The utility of both 3‐(1‐benzotriazolyl) chalcone derivatives 3a‐c and 2‐(1‐benzotriazolyl)‐1,4‐pentadien‐3‐one (18) in the synthesis of some new 2‐(1 H )‐pyridone, pyridine, pyrazole and isoxazole derivatives is reported. Antimicrobial and antifungal screening of some selected examples from the synthesized products were carried out. The structure of the newly synthesized compounds was elucidated by elemental analysis, ir, 1 H and 13 C nmr investigations.