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Alkylation of 2‐pyridinones: Synthesis of novel acyclonucleosides
Author(s) -
ElEssawy Farag A.,
Khattab Ahmed F.
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410302
Subject(s) - chemistry , alkylation , pyridine , side chain , combinatorial chemistry , organic chemistry , catalysis , polymer
This paper presents the synthesis of some novel acyclonucleosides containing 2‐pyridinones and 2‐hydroxyethoxymethyl, 2,3‐dihydroxy‐propyl side chain. The tosylate of these nucleosides analogues could be modified to azido derivatives. Also, acyclonucleosides with 1‐ethoxymethyl, 1‐benzyloxymethyl, 1‐methylthiomethy 1 and 2‐hydroxyethyl side chains have been investigated. The O ‐alkylated pyridine derivatives were obtained during most reactions.