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Efficient synthesis in three steps and spectral determination of methyl‐5‐[( o ‐, m ‐, and p ‐substituted‐phenylthio]‐2‐benzimidazolecarbamates
Author(s) -
Cortés Eduardo Cortés,
Mendoza Rafael Sosa,
Gutiérrez Maximiliano Santibáñez,
De Cortés Olivia GarcéaMellado
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410220
Subject(s) - chemistry , condensation , ether , ethanol , proton nmr , sulfate , spectral analysis , organic chemistry , carbon 13 nmr , medicinal chemistry , stereochemistry , spectroscopy , physics , quantum mechanics , thermodynamics
The preparation and spectral properties often novel methyl 5‐[( o ‐, m ‐, and p ‐substituted)‐phenylthio]‐2‐benzimidazolecarbamates with possible pharmacological activity as antihelmintics is described; by condensation and cyclization between 5‐methylthioures sulfate chloroformic acid methyl ester and 3,4‐diaminophenyl‐substituted‐phenylthio ether dissolved in ethanol. The structures of all final products were corroborated by ir; 1 H‐nmr, 13 C‐nmr and ms.