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Synthesis and physicochemical characterization of fluorescent ( E )‐2‐stilbenyloxyalkylthiouracils and isomer differentiation using EIMS
Author(s) -
Wyrzykiewicz Elzbieta,
Wendzonka Monika
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410207
Subject(s) - chemistry , heteronuclear molecule , fragmentation (computing) , fluorescence , spectral line , mass spectrum , ion , metastability , structural isomer , proton nmr , stereochemistry , nmr spectra database , nuclear magnetic resonance spectroscopy , organic chemistry , physics , quantum mechanics , operating system , astronomy , computer science
Twelve new fluorescent ( E )‐2‐stilbenyloxyalkylthiouracils and 6‐methyluracils 5a‐51 were prepared. EI induced mass spectral fragmentation of these compounds was investigated. Fragmentation pathways are proposed on the basis of accurate mass and metastable transition measurements. Correlation between the intensities of the M + and the selected fragment ions of these compounds is discussed. The data obtained permit a distinction of the metamers. The 1 H and 13 C NMR spectra of these compounds were assigned unambiguously using a combination of heteronuclear (HETCOR) spectra and the chemical shifts. The data derived from these spectra can be used to differentiate the isomers.