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Synthesis, characterization and biological activity of bis(3‐Aryl‐1‐hexahydropyrimidinyl)methanes. Novel heterocyclic polyamine derivatives
Author(s) -
Bisceglia Juan Á,
García María B.,
Massa Rosana,
Magri María L.,
Zani Mariana,
Gutkind Gabriel O.,
Orelli Liliana R.
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410113
Subject(s) - chemistry , aryl , methylene , polyamine , formaldehyde , condensation , organic chemistry , biological activity , combinatorial chemistry , in vitro , biochemistry , alkyl , physics , thermodynamics
A method is described for the synthesis of bis(3‐aryl‐1‐hexahydropyrimidinyl)methanes 1, by condensation of N ‐aryl‐1,3‐propanediarnines 2 with formaldehyde. The reaction mechanism involves N ‐arylhexahydropyrimidines 3 as intermediates. Such compounds can also be prepared efficiently by a methylene exchange reaction between bis‐hexahydropyrimidines 1 and the corresponding diamines 2. The antimicrobial activity of compounds 1 was evaluated by the disk diffusion method and some of them showed moderate to good growth inhibition activity.