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Simple and efficient cleavage reaction of the boc group in heterocyclic compounds
Author(s) -
Nadia Klai,
Malika Berredjem,
Nawel Khettache,
Yazid Belghit Med,
Zine Régaïnia,
Aouf NourEddine
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410109
Subject(s) - chemistry , regioselectivity , yield (engineering) , isocyanate , cleavage (geology) , group (periodic table) , organic chemistry , medicinal chemistry , stereochemistry , combinatorial chemistry , catalysis , materials science , geotechnical engineering , fracture (geology) , engineering , metallurgy , polyurethane
Dedicated to the memory of Pr. Ladjama Daif A series of chiral cyclosulfamides have been synthesized by alkaline cyclisation starting from N‐benzoylamino acids (Ala, Val, Leu, Phe) derivatives and chlorosulfonyl isocyanate. A simplified and regioselective deprotection of the cyclic compounds ( cyclosulfamides ) containing the tert ‐butyloxycarbonyl group (Boc) has been achieved in good yield by fusion under reduced pressure.