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2,4‐Dinitroimidazole: Microwave assisted synthesis and use in synthesis of 2,3‐dihydro‐6‐nitroimidazo[2,1‐ b ]oxazole analogues with antimycobacterial activity
Author(s) -
Bhaumik Kankan,
Akamanchi K. G.
Publication year - 2004
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570410108
Subject(s) - antimycobacterial , chemistry , oxazole , microwave irradiation , mycobacterium tuberculosis , stereochemistry , microwave , combinatorial chemistry , strain (injury) , organic chemistry , tuberculosis , catalysis , medicine , pathology , physics , quantum mechanics
2,4‐Dinitroimidazole (2,4‐DNI), an important starting material for nitroimidazooxazole and nitroimidazooxazine types of antitubercular agents was synthesized by rearrangement of 1,4‐dinitroimidazole (1,4‐DNI) under microwave irradiation. Various new nitroimidazooxazoles analogues were prepared using 2,4‐DNI and were tested preliminarily against Mycobacterium tuberculosis , H 37 Rv strain. Some were found to be active.