Synthesis of pyridazine derivatives through the unexpected intermediate 5‐amino‐ 4‐cyano ‐2,3‐dihydro‐furan‐2,3‐disulfonic acid disodium salt | Zendy

Cacciari Barbara | Zendy; Spalluto Giampiero | Zendy; Ferretti Valeria | Zendy

Premium

Synthesis of pyridazine derivatives through the unexpected intermediate 5‐amino‐ 4‐cyano ‐2,3‐dihydro‐furan‐2,3‐disulfonic acid disodium salt

Author(s) -

Cacciari Barbara,

Spalluto Giampiero,

Ferretti Valeria

Publication year - 2003

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570400615

Subject(s) - chemistry , malononitrile , pyridazine , salt (chemistry) , yield (engineering) , reactivity (psychology) , hydrazine (antidepressant) , sulfite , furan , medicinal chemistry , organic chemistry , catalysis , medicine , materials science , alternative medicine , pathology , chromatography , metallurgy

An unexpected compound (5‐amino‐4‐cyano‐2,3‐dihydrofuran‐2,3‐disulfonic acid disodium salt, 4 ) was isolated from the reaction of glyoxale bis hydrogen sulfite disodium salt with malononitrile. Its structure was undoubtly identified through crystal structure analysis. Compound 4 was highly stable and it was isolated easily and in a very high yield. Its reactivity was studied in the reactions with some hydrazine derivatives in order to obtain different pyridazine analogs.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research