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Synthesis of pyridazine derivatives through the unexpected intermediate 5‐amino‐ 4‐cyano ‐2,3‐dihydro‐furan‐2,3‐disulfonic acid disodium salt
Author(s) -
Cacciari Barbara,
Spalluto Giampiero,
Ferretti Valeria
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400615
Subject(s) - chemistry , malononitrile , pyridazine , salt (chemistry) , yield (engineering) , reactivity (psychology) , hydrazine (antidepressant) , sulfite , furan , medicinal chemistry , organic chemistry , catalysis , medicine , materials science , alternative medicine , pathology , chromatography , metallurgy
An unexpected compound (5‐amino‐4‐cyano‐2,3‐dihydrofuran‐2,3‐disulfonic acid disodium salt, 4 ) was isolated from the reaction of glyoxale bis hydrogen sulfite disodium salt with malononitrile. Its structure was undoubtly identified through crystal structure analysis. Compound 4 was highly stable and it was isolated easily and in a very high yield. Its reactivity was studied in the reactions with some hydrazine derivatives in order to obtain different pyridazine analogs.