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Liquid‐phase synthesis of mixture‐based bicyclic β‐lactam libraries
Author(s) -
Gedey Szilvia,
Fülöp Ferenc,
Vainiotalo Pirjo,
De Witte Peter A. M.,
Zupkó Istvían
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400601
Subject(s) - alicyclic compound , chemistry , bicyclic molecule , lactam , component (thermodynamics) , phase (matter) , combinatorial chemistry , ring (chemistry) , liquid phase , stereochemistry , organic chemistry , physics , thermodynamics
Five sets of 27‐membered combinatorial libraries of alicyclic β‐lactams were prepared via liquid‐phase Ugi 4‐center 3‐component reactions (U‐4C‐3CR) utilizing 3 different cis β‐amino acids, 3 different isonitriles and 5×3 sets of aldehydes. Through combinations of the building blocks of one of these libraries, all of the possible sublibraries were also generated. A few azetidinone derivatives were synthesized individually by parallel synthesis.