Liquid‐phase synthesis of mixture‐based bicyclic β‐lactam libraries | Zendy

Gedey Szilvia | Zendy; Fülöp Ferenc | Zendy; Vainiotalo Pirjo | Zendy; De Witte Peter A. M. | Zendy; Zupkó Istvían | Zendy

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Liquid‐phase synthesis of mixture‐based bicyclic β‐lactam libraries

Author(s) -

Gedey Szilvia,

Fülöp Ferenc,

Vainiotalo Pirjo,

De Witte Peter A. M.,

Zupkó Istvían

Publication year - 2003

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570400601

Subject(s) - alicyclic compound , chemistry , bicyclic molecule , lactam , component (thermodynamics) , phase (matter) , combinatorial chemistry , ring (chemistry) , liquid phase , stereochemistry , organic chemistry , physics , thermodynamics

Five sets of 27‐membered combinatorial libraries of alicyclic β‐lactams were prepared via liquid‐phase Ugi 4‐center 3‐component reactions (U‐4C‐3CR) utilizing 3 different cis β‐amino acids, 3 different isonitriles and 5×3 sets of aldehydes. Through combinations of the building blocks of one of these libraries, all of the possible sublibraries were also generated. A few azetidinone derivatives were synthesized individually by parallel synthesis.

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