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Synthesis of water‐soluble near‐infrared cyanine dyes functionalized with [(succinimido)oxy]carbonyl group
Author(s) -
Strekowski Lucjan,
Mason Christian J.,
Lee Hyeran,
Gupta Rajni,
Sowell John,
Patonay Gabor
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400527
Subject(s) - cyanine , chemistry , chromophore , infrared , fluorophore , carbonyl group , photochemistry , molecule , crystallization , biomolecule , organic chemistry , fluorescence , stereochemistry , biochemistry , physics , quantum mechanics , optics
Two hetamethine cyanine dyes suitable for labeling of biomolecules at a primary amino group with a near‐infrared chromophore/fluorophore (λ max /(λ em = 800/830 nm and 837/864 nm) have been synthesized from readily available starting materials. Despite the high molecular complexity of intermediate and final products, all these compounds have been obtained in an analytically pure form by using crystallization only.