Hypervalent iodine in synthesis 93. A facile synthesis of 2‐substituted imidazo[1,2‐ a ]pyrimidines by cyclocondensation of alkynyl(phenyl)iodonium salts and 2‐aminopyrimidine | Zendy

Liu Zhi | Zendy; Chen ZhenChu | Zendy; Zheng QinGuo | Zendy

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Hypervalent iodine in synthesis 93. A facile synthesis of 2‐substituted imidazo[1,2‐ a ]pyrimidines by cyclocondensation of alkynyl(phenyl)iodonium salts and 2‐aminopyrimidine

Author(s) -

Liu Zhi,

Chen ZhenChu,

Zheng QinGuo

Publication year - 2003

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570400526

Subject(s) - hypervalent molecule , chemistry , iodine , organic chemistry , combinatorial chemistry , medicinal chemistry

Simple stirring of a mixture of the alkynyl(phenyl)iodonium salts 1 with 2‐aminopyrimidine 2 in chloroform under reflux for two hours in the presence of K 2 CO 3 gave, after workup, the 2‐substituted imidazo[1,2‐α]pyrimidines 3 in moderate to good yields. A possible mechanism for the formation of 3 involves the intramolecular cyclization of the intermediate alkylidenecarbene 6.

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