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Synthesis of 1‐nonanoyl/octadecanoyl‐4‐substituted thiosemicarbazides and substituted 1,2,4‐trizoles as biological active compounds
Author(s) -
ColanceskaRagenovic Katica,
Dimova Vesna,
Kakurinov Vlado,
Gabor Dora Molnar
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400525
Subject(s) - chemistry , antimicrobial , alkyl , aryl , bacteria , organic chemistry , medicinal chemistry , combinatorial chemistry , genetics , biology
4‐Alkyl/aryl‐5‐nonanoyl/octadecanoyl‐2,4‐dihydro‐3 H ‐1,2,4‐triazoline‐3‐thiones were synthesized as potential antimicrobial agents. The course of synthesis included the reaction of nonanoyl/octadecanoyl hydrazines with selected alkyl/aryl isothiocyanates. The prepared thiosemicarbazides gave by cyclization the required 1,2,4‐triazoles. A number of synthesized compounds were subjected to in vitro testing against two gram‐positive, two gram‐negative bacteria and two fungi.