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Relative ortho ‐directing power of fluorine, chlorine and methoxy group for the metalation reaction in the diazine series. Diazines XXXV
Author(s) -
Toudic Frédéric,
Turck Alain,
Plé Nelly,
Quéguiner Guy,
Darabantu Mircea,
Lequeux Thierry,
Pommelet Jean Claude
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400517
Subject(s) - chemistry , metalation , regioselectivity , diazine , medicinal chemistry , chlorine , chlorine atom , organic chemistry , stereochemistry , catalysis
The regioselectivity of the metalation of 2‐chloro‐6‐methoxypyrazine, 2‐fluoro‐6‐methoxypyrazine and 3‐fluoro‐6‐chloropyridazine was studied; the relative ortho ‐directing power was F > OMe > Cl.