Premium
Synthesis of tricyclic pyrido[2,3‐b][1,4]‐thiazines via nucleophilic substitution of activated precursors
Author(s) -
Weber Manuela,
Jäger Walter,
Erker Thomas
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400516
Subject(s) - tricyclic , chemistry , benzothiazine , nucleophilic substitution , nucleophile , smiles rearrangement , nucleophilic aromatic substitution , substitution (logic) , stereochemistry , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , computer science , programming language
Pyrido‐anellated compounds analogous to tricyclic 1,4‐benzothiazine derivatives were synthesized. Thus, under mild reaction conditiones substitution of thiolactim 3 with different N ‐nucleophiles yielded the precursors for compounds, which were cyclized in a further step to the corresponding tricyclic derivatives.