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Synthesis of N 1 ‐substituted coumarino[4,3‐c] pyrazoles
Author(s) -
Čačič Milan,
Trkovnik Mladen,
HasSchön Elizabeta
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400513
Subject(s) - chemistry , pyrazole , hydrazide , acetic acid , alkyl , medicinal chemistry , stereochemistry , organic chemistry
3‐Acyl‐4‐hydroxy‐2‐oxo‐2 H ‐chromen derivatives 1a‐d were condensed with (7‐hydroxy‐2‐oxo‐2 H ‐chromen‐4‐yl)‐acetic acid hydrazide 2 , (4‐methyl‐2‐oxo‐2 H ‐chromen‐7‐yloxy)‐acetic acid hydrazide 3 , and (7‐hydrazinocarbonylmethoxy‐2‐oxo‐2 H ‐chromen‐4‐yl)‐acetic acid hydrazide 4 , to give corresponding 3‐alkyl‐1‐[2‐(7‐hydroxy‐2‐oxo‐2 H ‐chromeno‐4‐yl)‐acetyl]‐1 H ‐chromeno[4,3‐ c ]pyrazole‐4‐one 5a‐d , 3‐alkyl‐1‐[2‐(4‐methyl‐2‐oxo‐2 H ‐chromeno‐7‐yloxy)‐acetyl]‐1 H ‐chromeno[4,3‐ c ]pyrazole‐4‐one 6a‐d , and 1‐{4‐[(3‐alkyl‐1 H ‐chromeno[4,3‐ c ]pyrazole‐4‐one‐1‐yl)‐carbonylmethyl]‐2‐oxo‐2 H ‐chromen‐7‐yloxy‐acetyl}‐3‐alkyl‐1 H ‐chromeno[4,3‐ c ]pyrazole‐4‐one 7a‐d.