Synthesis and  15 N NMR characterization of 4‐vinylbenzyl substituted bases of nucleic acids | Zendy

Sedlák Miloš | Zendy; Šimůnek Petr | Zendy; Antonietti Markus | Zendy

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Synthesis and 15 N NMR characterization of 4‐vinylbenzyl substituted bases of nucleic acids

Author(s) -

Sedlák Miloš,

Šimůnek Petr,

Antonietti Markus

Publication year - 2003

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570400418

Subject(s) - chemistry , thymine , cytosine , alkylation , uracil , monomer , guanine , anhydrous , nucleic acid , iodide , polymerization , polymer , organic chemistry , dna , catalysis , nucleotide , biochemistry , gene

The following substances have been synthesized and characterized as monomers or intermediates for syntheses of new polymers: 1‐(4‐vinylbenzyl)uracil ( 1a ), 1‐(4‐vinylbenzyl)thymine ( 1b ), N ‐4‐acetyl‐1‐(4‐vinylbenzyl)cytosine ( 1c ), 1‐(4‐vinylbenzyl)cytosine ( 1d ), 9‐(4‐vinylbenzyl)adenine ( 2a ), 2‐amino‐9‐(4‐vinylbenzyl)‐6‐chloro‐9 H ‐purine ( 2b ), and 9‐(4‐vinylbenzyl)‐guanine ( 2c ). The alkylation reactions with 4‐vinylbenzyl chloride were catalyzed with anhydrous sodium iodide. The substitution at position 9 in substances 2a‐c was confirmed by 15 N NMR.

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