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2‐(4‐methylpyridin‐2‐yl)‐1 H ‐benzimidazole derivatives. Part II, l H nmr characterization
Author(s) -
Barni Ermanno,
Barolo Claudia,
Quagliotto Pierluigi,
Savarino Piero,
Viscardi Guido,
Marabello Domenica
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400414
Subject(s) - chemistry , benzimidazole , imidazole , tautomer , hydrogen bond , proton nmr , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , crystallography , medicinal chemistry , molecule , organic chemistry
Abstract A selected series of 2‐(4‐methylpyridin‐2‐yl)‐1 H ‐benzimidazole derivatives, bases and cyclic mono‐ and bis‐salts, were synthesized. Complete '1 H nmr characterization is reported. Ambiguous assignments were solved using 1 H‐ 1 H NOESY analysis. Significant ir and 1 H nmr data are presented concerning: i) tautomeric equilibrium of imidazole hydrogen; ii) hydrogen bonds; iii) conformational inversion of partially saturated rings.