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Synthesis of heteroaryl substituted α‐mercapto acids from thiomalic acid using hexafluoroacetone as protecting and activating reagent
Author(s) -
Pumpor Ksenia,
Windeisen Elisabeth,
Burger Klaus
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400306
Subject(s) - chemistry , hexafluoroacetone , reagent , depsipeptide , combinatorial chemistry , organic chemistry , stereochemistry
The synthesis of heterocyclic α‐mercapto acids starting from ( RS )‐thiomalic acid using hexafluoroacetone as protecting and activating agent is described. The new compounds are useful building blocks for peptide and depsipeptide modification as well as for drug design.