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Synthesis of novel 2‐amino‐1,3‐thiazole‐5‐carboxylates utilising ultrasonic and thermally mediated aminolysis
Author(s) -
Baker Luke A.,
Williams Craig M.
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400225
Subject(s) - aminolysis , chemistry , thiazole , ultrasonic sensor , organic chemistry , combinatorial chemistry , catalysis , physics , acoustics
Novel 2‐amino‐1,3‐thiazole‐5‐carboxylates have been synthesised in high yield by unprecedented ultrasonic and thermally mediated nucleophilic displacement of bromide from ethyl 2‐bromo‐1,3‐thiazole‐5‐car‐boxylate by primary, secondary and aryl amines.