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Synthesis and bioactivity of xyridin A and B, metabolites from xyris indica
Author(s) -
Saeed Aamer
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400222
Subject(s) - chemistry , saponification , antifungal , methylenedioxy , chloride , isocoumarins , in vitro , condensation , organic chemistry , antibacterial activity , stereochemistry , biochemistry , bacteria , microbiology and biotechnology , catalysis , genetics , halogen , biology , alkyl , thermodynamics , physics
A facile synthesis of the title isocoumarins isolated from. Xyris indica was accomplished. Condensation of butanoyl chloride and 2‐oxo‐butanoyl chloride with 3,4‐methylenedioxyhomophthalic acid afforded xyridin A and xyridin B respectively. Xyridin A was saponified to the corresponding keto acid which on reduction furnished the (±)‐3,4‐dihydro‐6,7‐methylenedioxy‐3‐propylisocoumarin. All of the synthesized compounds were examined in vitro for antibacterial and antifungal activities.