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New heterocycles from 8‐hydroxyquinoline via dipolar 1,3‐cycloadditions: Synthesis & biological evaluation
Author(s) -
Bahloul Abdelmejid,
Sebban Abdelfatah,
Dardari Zainaba,
Boudouma Mohammed,
Kitane Said,
Belghiti Touria,
Joly JeanPierre
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400207
Subject(s) - chemistry , 8 hydroxyquinoline , combinatorial chemistry , in vitro , dipole , organic chemistry , stereochemistry , computational chemistry , biochemistry
Diarylnitrilimine and arylnitriloxide dipoles react with two 8‐hydroxyquinoline substrates to give respectively pyrazolinic and isoxazolinic derivatives. The structure of these new heterocycles was established on the basis of their spectroscopic data and by chemical methods. The inhibition activity of one of these heterocycles was evaluated in vitro against 8 pathogenic μ‐organisms.