Synthesis of new uracil non‐nucleoside derivatives as potential inhibitors of HIV‐1 | Zendy

ElEssawy Farag A. | Zendy; ElBrollosy Nasser R. | Zendy; Pedersen Erik B. | Zendy; Nielsen Claus | Zendy

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Synthesis of new uracil non‐nucleoside derivatives as potential inhibitors of HIV‐1

Author(s) -

ElEssawy Farag A.,

ElBrollosy Nasser R.,

Pedersen Erik B.,

Nielsen Claus

Publication year - 2003

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570400203

Subject(s) - chemistry , uracil , ether , bromide , nucleoside , alkyl , benzyl bromide , halide , organic chemistry , medicinal chemistry , stereochemistry , biochemistry , catalysis , dna

6‐(2‐Phenylethyl) and 6‐cyclohexyl 5‐cyanouracils ( 1a,b ) were synthesized and reacted with chloromethyl ethyl ether, benzyl chloromethyl ether, chloromethyl methyl sulfide and (2‐acetoxyethoxy)methyl bromide. New uracil analogues of ( S )‐DHPA were synthesized by reaction of compounds ( 1a,b ) with (( S )‐2,2‐dimethyl‐1,3‐dioxolane‐4‐yl) alkyl p ‐toluenesulfonate.

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