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Synthesis of new uracil non‐nucleoside derivatives as potential inhibitors of HIV‐1
Author(s) -
ElEssawy Farag A.,
ElBrollosy Nasser R.,
Pedersen Erik B.,
Nielsen Claus
Publication year - 2003
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570400203
Subject(s) - chemistry , uracil , ether , bromide , nucleoside , alkyl , benzyl bromide , halide , organic chemistry , medicinal chemistry , stereochemistry , biochemistry , catalysis , dna
Abstract 6‐(2‐Phenylethyl) and 6‐cyclohexyl 5‐cyanouracils ( 1a,b ) were synthesized and reacted with chloromethyl ethyl ether, benzyl chloromethyl ether, chloromethyl methyl sulfide and (2‐acetoxyethoxy)methyl bromide. New uracil analogues of ( S )‐DHPA were synthesized by reaction of compounds ( 1a,b ) with (( S )‐2,2‐dimethyl‐1,3‐dioxolane‐4‐yl) alkyl p ‐toluenesulfonate.