Studies towards the synthesis of the benzodiazepine alkaloid auranthine | Zendy

Witt Anette | Zendy; Gustavsson Annika | Zendy; Bergan Jan | Zendy

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Studies towards the synthesis of the benzodiazepine alkaloid auranthine

Author(s) -

Witt Anette,

Gustavsson Annika,

Bergan Jan

Publication year - 2003

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570400103

Subject(s) - chemistry , diazepine , benzodiazepine , derivative (finance) , acetylation , alkaloid , dehydration , butyric acid , organic chemistry , total synthesis , stereochemistry , ring (chemistry) , biochemistry , receptor , financial economics , economics , gene

Different approaches towards the synthesis of auranthine have been investigated. A completed synthesis of 3‐[2‐(4‐oxo‐3,4‐dihydro‐quinazolin‐2‐yl)‐3,4‐dihydro‐1H‐benzo[e][1,4]‐diazepine‐2,5‐dione, an auranthine precursor, which after dehydration with 50% propylphophonic acid anhydride solution in ethl acetate and DMA gave a C‐acetyl derivative of aurnathine. Additionally studies towards the synthesis of fused quinazolinones yielded the C‐acetylated pyrido[2,1‐b]quinazolinones or butyric acid derivatives.

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