Synthesis and spectral properties of 2‐methylthio‐3 H ‐7‐[( o ‐;  m ‐ and  p ‐substituted)phenoxy]‐4‐( p ‐substituted‐phenyl)‐[1,5]benzodiazepines | Zendy

Cortés Eduardo Cortés | Zendy; Romero Cristina A. Cortés | Zendy; Mellado Olivia García | Zendy

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Synthesis and spectral properties of 2‐methylthio‐3 H ‐7‐[( o ‐; m ‐ and p ‐substituted)phenoxy]‐4‐( p ‐substituted‐phenyl)‐[1,5]benzodiazepines

Author(s) -

Cortés Eduardo Cortés,

Romero Cristina A. Cortés,

Mellado Olivia García

Publication year - 2002

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570390633

Subject(s) - chemistry , sodium hydride , medicinal chemistry , sodium iodide , methyl iodide , proton nmr , hydride , iodide , spectral properties , stereochemistry , organic chemistry , computational chemistry , hydrogen

A series of eleven new 2‐methylthio‐3 H ‐7‐[( o ‐; m ‐ and p ‐substituted) phenoxy]‐4‐( p ‐substituted‐phenyl)‐[1,5]benzodiazepines, which have potentially useful pharmacological activities, has been synthesized by condensing the 4‐[( o ‐; m ‐ and p ‐R 1 )phenoxy]‐1,2‐phenylendiamines with 3,3‐dimercapto‐1‐( p ‐R 2 ‐phenyl)‐2‐propen‐1‐one. Afterward the l H ‐[1,5]benzodiazepine‐2‐thiones obtained were treated with sodium hydride and methyl iodide. The structure of all products was corroborated by ir, 1 H nmr, 13 C nmr and ms.

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