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Study of the heterocyclization of vic ‐substituted hydrazides of acetylenylpyrazolecarboxylic acids into N ‐amino pyrazolopyridinones
Author(s) -
Vasilevsky Sergei F.,
Mshvidobadze Elena V.,
Elguero José
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390617
Subject(s) - chemistry , amino acid , pyrazole , medicinal chemistry , organic chemistry , stereochemistry , combinatorial chemistry , biochemistry
We report a new and efficient methodology to prepare N ‐amino pyrazolo[4,3‐ c ]pyridin‐4‐ones 4 and N ‐amino pyrazolo[3,4‐ c ]pyridin‐4‐ones 8 from vic ‐acetylenyl/hydrazido pyrazoles. The procedure involves the intermediate synthesis of methyl esters of acetylenyl‐pyrazole carboxylic acids and the subsequent cyclization under a variety of conditions.