Study of the heterocyclization of  vic ‐substituted hydrazides of acetylenylpyrazolecarboxylic acids into  N ‐amino pyrazolopyridinones | Zendy

Vasilevsky Sergei F. | Zendy; Mshvidobadze Elena V. | Zendy; Elguero José | Zendy

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Study of the heterocyclization of vic ‐substituted hydrazides of acetylenylpyrazolecarboxylic acids into N ‐amino pyrazolopyridinones

Author(s) -

Vasilevsky Sergei F.,

Mshvidobadze Elena V.,

Elguero José

Publication year - 2002

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570390617

Subject(s) - chemistry , amino acid , pyrazole , medicinal chemistry , organic chemistry , stereochemistry , combinatorial chemistry , biochemistry

We report a new and efficient methodology to prepare N ‐amino pyrazolo[4,3‐ c ]pyridin‐4‐ones 4 and N ‐amino pyrazolo[3,4‐ c ]pyridin‐4‐ones 8 from vic ‐acetylenyl/hydrazido pyrazoles. The procedure involves the intermediate synthesis of methyl esters of acetylenyl‐pyrazole carboxylic acids and the subsequent cyclization under a variety of conditions.

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