Synthesis and ring transformation of substituted  S ‐(1‐phenylpyrrolidine‐2‐ones‐3‐yl)isothiuronium salts to substituted 2‐imino‐5‐[2‐(phenylamino)ethyl]thiazolidin‐4‐ones | Zendy

Sedlák MiloŠ | Zendy; Hanusek JiŘí | Zendy; Macháček Vladimír | Zendy; Hejtmánková Ludmila | Zendy

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Synthesis and ring transformation of substituted S ‐(1‐phenylpyrrolidine‐2‐ones‐3‐yl)isothiuronium salts to substituted 2‐imino‐5‐[2‐(phenylamino)ethyl]thiazolidin‐4‐ones

Author(s) -

Sedlák MiloŠ,

Hanusek JiŘí,

Macháček Vladimír,

Hejtmánková Ludmila

Publication year - 2002

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570390543

Subject(s) - chemistry , thiazolidine , ring (chemistry) , intramolecular force , medicinal chemistry , lactam , stereochemistry , organic chemistry

Dedicated to Professor Jaromír Kaválek on the occasion of his 65 th birthday Substituted S ‐(1‐phenylpyrrolidin‐2‐on‐3‐yl)isothiuronium salts in weakly basic media undergo intramolecular recyclisation reaction in which the γ‐lactam cycle is split and a thiazolidine cycle is formed. A series of six substituted 2‐imino‐5‐[2‐(phenylamino)ethyl]‐thiazolidin‐4‐ones have been prepared by this reaction.

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