Synthesis of pyrrolidine based natural or unnatural product derivatives (1): Application of efficient asymmetric induction of C‐2 position in polysubstituted pyrrolidines | Zendy

Jeong Hyung Jae | Zendy; Lee Ju Man | Zendy; Kim Min Kyu | Zendy; Lee SangGyeong | Zendy

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Synthesis of pyrrolidine based natural or unnatural product derivatives (1): Application of efficient asymmetric induction of C‐2 position in polysubstituted pyrrolidines

Author(s) -

Jeong Hyung Jae,

Lee Ju Man,

Kim Min Kyu,

Lee SangGyeong

Publication year - 2002

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570390525

Subject(s) - chemistry , stereocenter , pyrrolidine , natural product , succinimide , triethylsilane , asymmetric induction , stereoselectivity , stereochemistry , organic chemistry , combinatorial chemistry , enantioselective synthesis , catalysis

A novel method for synthesis of polysubstituted pyrrolidines, which possess a C‐2 stereocenter, was developed. The strategy involves Grignard addition to the succinimide, derived from L‐tartaric acid, followed by stereocontrolled triethylsilane promoted reduction of the resulting cyclic amidols.

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