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Synthesis of new 1,2‐dihydrophthalazines
Author(s) -
Lukács Gyula,
Simig Gyula
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390520
Subject(s) - chemistry , phthalazine , medicinal chemistry , combinatorial chemistry
New 6‐chloro‐ and 6,7‐dichloro‐4‐(4‐aminophenyl)‐2‐( N ‐alkylcarbamoyl)‐1,2‐dihydrophthalazines ( 12,18 ) were synthesized starting from 6‐chloro‐ and 6,7‐dichloro‐4‐(4‐nitrophenyl)phthalazine ( 8 ). Routes to 1‐unsubstituted ( 12 ) and 1‐methyl ( 18 ) derivatives are different. Key intermediates 8 were prepared from 4‐chloro‐ and 3,4‐dichlorotoluene via ortho ‐formylbenzophenone derivatives 7 .
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