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An efficient synthesis of a class of novel N ‐Alkyl‐ N ‐aryl‐4‐hydroxy‐1‐methyl‐2‐oxo‐1,2‐dihydro‐3‐quinolinecarbothioamides
Author(s) -
Spears Glen W.,
Tsuji Kiyoshi,
Tojo Takashi,
Nishimura Hiroaki,
Ogino Takashi
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390427
Subject(s) - chemistry , alkyl , yield (engineering) , aryl , amide , class (philosophy) , coupling (piping) , combinatorial chemistry , stereochemistry , organic chemistry , artificial intelligence , computer science , mechanical engineering , materials science , engineering , metallurgy
The novel title compounds have been prepared in high yield by an optimized amide coupling followed by a Dieckmann cyclization. Additionally, this new route is amenable to preparative scale synthesis.