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Synthesis and molecular structure of novel 4‐aryloctahydropyrido‐[1,2‐ c ]pyrimidine derivatives
Author(s) -
Herold Franciszek,
Kleps Jerzy,
Szczȩsna Beata,
AnulewiczOstrowska Romana
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390424
Subject(s) - chemistry , pyrimidine , acetamide , stereocenter , stereochemistry , intramolecular force , aryl , nuclear magnetic resonance spectroscopy , organic chemistry , catalysis , alkyl , enantioselective synthesis
A series of new 4‐aryloctahydropyrido[1,2‐ c ]pyrimidine‐1,3‐diones 6a,b,d‐h and j were synthesized by intramolecular cyclization of α‐aryl‐α‐(1‐ethoxycarbonyl‐2‐piperidyl)‐acetamide derivatives 5a,b,d‐h and j . The structures of compounds were determined by 1 H and 13 C nmr spectroscopy. Nmr and X‐ray diffraction data indicate that the configuration at the C4, C4a stereocenters constitute RR and SS pair.